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The Holocaust memorial museum is the fourth largest in the U.S. and opened in 1996.

The Museum's patron's first experience will include entry via the Morgan Family Welcome Center, complete with an orientation film and exhibition materials in both English and Spanish. The permanent Holocaust Gallery is personalized with testimony of Holocaust survivors who later settled in the Houston area, featuring artifacts donated by the survivors, their descendants, liberators, and other collectors.

The Museum also includes two changing galleries for art and photography exhibits. The Central Gallery is naturally located in the center of the Museum building. The Josef and Edith Mincberg Gallery is a larger hall for more extensive displays.

The Boniuk Library, with more than 10,000 volumes and numerous resources for in-house research and education, allows for enhanced public access to its 285 oral testimonies for research purposes and genealogical searches.